

Eight years after the third film, the OSS has become the world's top spy agency, while the Spy Kids department has since become defunct. Retired spy Marissa is called back into action, and to bond with her new stepchildren Rebecca and Cecil, she invites them along to stop the evil Timekeeper from taking over the world.
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Alexa PenaVega
Carmen Cortez

Daryl Sabara
Juni Cortez

Danny Trejo
Uncle Machete
Belle Solorzano
Spy Baby
Genny Solorzano
Spy Baby

Ricky Gervais
Voice of Argonaut
Elmo
Argonaut
Jett Good
Young Danger
Chuck Cureau
News Anchor
Albert Im
Head Scientist

Wray Crawford
Editor / Cameraman

Jonathan Breck
Wilbur's Boss
Alcides Dias
OSS Agent #1

Roger Edwards
OSS Agent #2

Angela Lanza
Female OSS Agent

Chad Guerrero
Henchman in Van

Marci Madison
Agent Fine

Antonio Banderas
Gregorio Cortez (uncredited)

Frank Welker
Animals' vocal effects (voice, uncredited)